
It has been used in Japan as a food additive for several decades as well, and owns a significant market share, not a single report of side effects of any kind has been reported.
Rebaudioside A, one of the key components of the Stevia leaf, has recently been approved in the United States as safe for food & beverage applications. In the European Union it is still not approved as a food product, however it is allowed to be used as a dental care ingredient, and judging by the recent developments in the United States, an approval in Europe is expected soon.
Elaborate safety tests were performed by the Japanese during their evaluations of stevia as a possible sweetening agent. Few substances have ever yielded such consistently negative results in toxicity trials as has stevia. Almost every toxicity test imaginable has been performed on stevia extract or stevioside at one time or another The results are always negative. No abnormalities in weight change, food intake, cell or membrane characteristics, enzyme and substrate utilization, or chromosome characteristics. No cancer,no birth defects, no acute and no chronic untoward effects.

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